Position Sensing from Charge Dispersion in Micro-Pattern Gas Detectors with a Resistive Anode

Micro-pattern gas detectors, such as the Gas Electron Multiplier (GEM) and the Micromegas need narrow high density anode readout elements to achieve good spatial resolution. A high-density anode readout would require an unmanageable number of electronics channels for certain potential micro-detector applications such as the Time Projection Chamber. We describe below a new technique to achieve good spatial resolution without increasing the electronics channel count in a modified micro-detector outfitted with a high surface resistivity anode readout structure. The concept and preliminary measurements of spatial resolution from charge dispersion in a modified GEM detector with a resistive anode are described below.Comment: 14 pages, 8 figures, submitted to Nucl. Inst. Meth; typo in eqn 4 corrected, fig 2 updated accordingl

Resolution studies of cosmic-ray tracks in a TPC with GEM readout

A large volume TPC is a leading candidate for the central tracking detector at a future high energy linear collider. To improve the resolution a new readout based on micro-pattern gas detectors is being developed. Measurements of the spatial resolution of cosmic-ray tracks in a GEM TPC are presented. We find that the resolution suffers if the readout pads are too wide with respect to the charge distribution at the readout plane due to insufficient charge sharing. For narrow pads of 2 x 6 mm**2 we measure a resolution of 100 micometer at short drift distances in the absence of an axial magnetic field. The dependence of the spatial resolution as a function of drift distance allows the determination of the underlying electron statistics. Our results show that the present technique uses about half the statistical power available from the number of primary electrons. The track angle effect is observed as expected.Comment: 18 pages, 8 figures, version as published in Nucl. Inst. Met

Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats

The insular cortex (IC) is involved in the generalization of epileptic discharges in temporal lobe epilepsy (TLE), while seizures originating in IC can mimic the epileptic phenotype seen in some TLE patients. Few studies have however addressed the changes occurring in the IC in TLE animal models. Here, we analyzed the immunohistochemical and electrophysiological properties of IC networks in non-epileptic control and pilocarpine-treated epileptic rats. Neurons identified with a neuron-specific nuclear protein antibody showed similar counts in the two types of tissue but parvalbumin- and neuropeptide Y-positive interneurons were significantly decreased (parvalbumin, approx. -35%; neuropeptide Y, approx. -38%; P<0.01) in the epileptic IC. Non-adapting neurons were more frequently seen in the epileptic IC during intracellular injection of depolarizing current pulses. In addition, single-shock electrical stimuli elicited network-driven epileptiform responses in 87% of epileptic and in 22% of non-epileptic control neurons (P<0.01) but spontaneous postsynaptic potentials had similar amplitude, duration and intervals of occurrence in the two groups. Finally, pharmacologically isolated, GABAA receptor-mediated inhibitory postsynaptic potentials had more negative reversal potential (P<0.01) and higher peak conductance (P<0.05) in epileptic tissue. These data reveal moderate increased network excitability in the IC of pilocarpine-treated epileptic rats. We propose that such limited degree of hyperexcitability originates from loss of parvalbumin- and neuropeptide Y-positive interneurons that is compensated by an increased drive for GABAA receptor-mediated inhibition

The feasibility of psychometric measures for body image and lymphedema for routine practice

YesResearch Question: To assess the feasibility of the MGSIS-5and G3L-20 in a community sample of cisgender men aged 40 years and older Research problem: Psychometric measures can aid urologic practice by prompting patients to talk about aspects of their body that are either too sensitive or a natural part of aging. Importantly, reliable and valid measures can also contribute to a an evidenced-based-practice-based-evidence cycle where they can establish the impact of changes recommended by research while using the results in turn to inform research. In this study, we examine two psychometric measures on the opposite ends of a psychological-physical continuum; the Male Genital Self-Image Scale (MGSIS-5) and the Groin and Lower Limb Lymphedema questionnaire (G3L-20) Methodology: Non-experimental psychometric design administering the questionnaires online to a community sample of cisgender men aged 40 years old and above. Validity and reliability analyses were conducted. Results: 30 men completed the study; 14 aged 40-49, 14 aged 50-59 and 2 aged 60-69. The MGSIS-5 and G3L-20 show acceptable reliability and validity with one- and three-component structures respectively. Conclusions: The MGSIS-5 and G3L-20 show sufficient feasibility to justify the resources for studies with larger community samples and for pilot studies with clinical populations

Automatic detection of fast oscillations (40-200 Hz) in scalp EEG recordings

Objective—We aim to automatically detect fast oscillations (40–200 Hz) related to epilepsy on scalp EEG recordings. Methods—The detector first finds localized increments of the signal power in narrow frequency bands. A simple classification based on two features, a narrowband to wideband signal amplitude ratio and an absolute narrowband signal amplitude, then allows for an important reduction in the number of false positives. Results—When compared to an expert, the performance in 15 focal epilepsy patients resulted in 3.6 false positives per minute at 95% sensitivity, with at least 40% of the detected events being true positives. In most of the patients the channels showing the highest number of events according to the expert and the automatic detector were the same. Conclusions—A high sensitivity is achieved with the proposed automatic detector, but results should be reviewed by an expert to remove false positives. Significance—The time required to mark fast oscillations on scalp EEG recordings is drastically reduced with the use of the proposed detector. Thus, the automatic detector is a useful tool in studies aiming to create a better understanding of the fast oscillations visible on the scalp.Facultad de Ingenierí

Mapping the Dabus Wetlands, Ethiopia, using random forest classification of Landsat, PALSAR and topographic data

The Dabus Wetland complex in the highlands of Ethiopia is within the headwaters of the Nile Basin and is home to significant ecological communities and rare or endangered species. Its many interrelated wetland types undergo seasonal and longer-term changes due to weather and climate variations as well as anthropogenic land use such as grazing and burning. Mapping and monitoring of these wetlands has not been previously undertaken due primarily to their relative isolation and lack of resources. This study investigated the potential of remote sensing based classification for mapping the primary vegetation groups in the Dabus Wetlands using a combination of dry and wet season data, including optical (Landsat spectral bands and derived vegetation and wetness indices), radar (ALOS PALSAR L-band backscatter), and elevation (SRTM derived DEM and other terrain metrics) as inputs to the non-parametric Random Forest (RF) classifier. Eight wetland types and three terrestrial/upland classes were mapped using field samples of observed plant community composition and structure groupings as reference information. Various tests to compare results using different RF input parameters and data types were conducted. A combination of multispectral optic

Does improved functional performance help to reduce urinary incontinence in institutionalized older women? a multicenter randomized clinical trial

<p>Abstract</p> <p>Background</p> <p>Urinary incontinence (UI) is a major problem in older women. Management is usually restricted to dealing with the consequences instead of treating underlying causes such as bladder dysfunction or reduced mobility.</p> <p>The aim of this multicenter randomized controlled trial was to compare a group-based behavioral exercise program to prevent or reduce UI, with usual care. The exercise program aimed to improve functional performance of pelvic floor muscle (PFM), bladder and physical performance of women living in homes for the elderly.</p> <p>Methods</p> <p>Twenty participating Dutch homes were matched and randomized into intervention or control homes using a random number generator. Homes recruited 6–10 older women, with or without UI, with sufficient cognitive and physical function to participate in the program comprising behavioral aspects of continence and physical exercises to improve PFM, bladder and physical performance. The program consisted of a weekly group training session and homework exercises and ran for 6 months during which time the control group participants received care as usual. Primary outcome measures after 6 months were presence or absence of UI, frequency of episodes (measured by participants and caregivers (not blinded) using a 3-day bladder diary) and the Physical Performance Test (blinded). Linear and logistic regression analysis based on the Intention to Treat (ITT) principle using an imputed data set and per protocol analysis including all participants who completed the study and intervention (minimal attendance of 14 sessions).</p> <p>Results</p> <p>102 participants were allocated to the program and 90 to care as usual. ITT analysis (n = 85 intervention, n = 70 control) showed improvement of physical performance (intervention +8%; control −7%) and no differences on other primary and secondary outcome measures. Per protocol analysis (n = 51 intervention, n = 60 control) showed a reduction of participants with UI (intervention −40%; control −28%) and in frequency of episodes (intervention −51%; control −42%) in both groups; improvement of physical performance (intervention + 13%; control −4%) was related to participation in the exercise program.</p> <p>Conclusions</p> <p>This study shows that improving physical performance is feasible in institutionalized older women by exercise. Observed reductions in UI were not related to the intervention. [Current Controlled Trials ISRCTN63368283]</p

Effect of Mono and Di-rhamnolipids on Biofilms Pre-formed by Bacillus subtilis BBK006.

Different microbial inhibition strategies based on the planktonic bacterial physiology have been known to have limited efficacy on the growth of biofilms communities. This problem can be exacerbated by the emergence of increasingly resistant clinical strains. Biosurfactants have merited renewed interest in both clinical and hygienic sectors due to their potential to disperse microbial biofilms. In this work, we explore the aspects of Bacillus subtilis BBK006 biofilms and examine the contribution of biologically derived surface-active agents (rhamnolipids) to the disruption or inhibition of microbial biofilms produced by Bacillus subtilis BBK006. The ability of mono-rhamnolipids (Rha-C10-C10) produced by Pseudomonas aeruginosa ATCC 9027 and the di-rhamnolipids (Rha-Rha-C14-C14) produced by Burkholderia thailandensis E264, and phosphate-buffered saline to disrupt biofilm of Bacillus subtilis BBK006 was evaluated. The biofilm produced by Bacillus subtilis BBK006 was more sensitive to the di-rhamnolipids (0.4 g/L) produced by Burkholderia thailandensis than the mono-rhamnolipids (0.4 g/L) produced by Pseudomonas aeruginosa ATCC 9027. Rhamnolipids are biologically produced compounds safe for human use. This makes them ideal candidates for use in new generations of bacterial dispersal agents and useful for use as adjuvants for existing microbial suppression or eradication strategies